IMMUNOPATHOGENESIS AND MODERN POSSIBILITIES OF TREATMENT OF ATOPIC DERMATITIS IN CHILDREN

SEMINAR

P. 12-22

I.I. Balabolkin 1, V.A. Bulgakova 1, T.I. Eliseeva 2

 

1 FSAI «National Scientific and Practical Center of Children’s Health» of the Ministry of Health of the Russian Federation, Moscow, Russia

2 State Educational Establishment of Higher Professional Training Nizhny Novgorod State Medical Academy of the Ministry of Public Health of the Russian Federation, Nizhny Novgorod, Russia

 

The article discusses the immunological aspects of pathogenesis and treatment of atopic dermatitis (AtD) in children. It shows the importance of genetically determined Th2-immune response in the development of the disease. There are two AtD types: IgE-mediated and non-IgE-mediated. Pathogenetic basis of AtD is skin inflammation that occurs as a result of activation of Th2, Th1, Th17, dendritic and mast cells, eosinophils, basophils, keratinocytes, increased mediators, cytokines, adhesion molecules production. The article proves the effectiveness of allergen specific immunotherapy for IgE-mediated AtD and concomitant bronchial asthma, immunosuppressive therapy with cyclosporine and targeted therapy with biological agents for resistant to standard pharmacotherapy forms of AtD and possibility of immunomodulators use for disease course associated with bacterial or viral infection.

 

Keywords: atopic dermatitis, IgE-mediated, no IgE-mediated, Th2-, Th1-, Th17-lymphocytes, dendritic cells, mast cells, eosinophils, basophils, keratinocytes, cytokines, adhesion molecules, allergen immunotherapy, targeted therapy, Cyclosporin A, immunomodulating therapy.

 

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