ORIGINAL ARTICLE. EVALUATION OF IMMUNOLOGICAL INDICATORS IN CHILDREN WITH ASTHMA IN DEPENDENCE ON THE DURATION OF THE DISEASE

P. 19-24

E.G. Asiryan1, N.D. Titova2, Ya.V. Sobolevskaya3

 

1 Vitebsk State Medical University, Vitebsk, Belarus

2 Belarusian Medical Academy of Postgraduate Education, Minsk, Belarus

3 «Vitebsk Regional Children’s Clinical Center» Regional Clinical Children’s Hospital, Vitebsk, Belarus

 

The purpose of the study is to study the indices of the immune status of children with bronchial asthma, depending on the duration of the disease.

Materials and methods. The examination included 110 children with atopic bronchial asthma aged 6 to 18 years. The first group included 37 children, the duration of the disease is less than three years. The second group consisted of 73 patients, observed for bronchial asthma for more than three years. In the course of the study, the levels of CD3+, CD4+, CD4+CD25+ T-lymphocytes, CD19+, CD19+CD23++ B-lymphocytes, CD203c+, CD203c+CD63+, CD203c+IgE+ basophils were studied.

Results. The study found that the absolute level of CD3+ T-lymphocytes and CD19+ B-lymphocytes in children with a disease duration of more than three years was statistically significantly lower (p<0.05). The relative and absolute levels of CD19+CD23++ B–lymphocytes are significantly higher in children with bronchial asthma in both groups than in the control group (p<0.01). The relative level of CD203c+CD63+ bazophiles is statistically significantly higher in children with a disease duration of more than three years (p<0.05). The absolute level of this indicator, as well as the relative and absolute level of CD203c+IgE+ basophils in both groups of children with bronchial asthma is significantly higher than in the control group children who do not have allergic diseases (p<0.05).

The conclusion. The features of the immune status in children with bronchial asthma are revealed depending on the duration of the disease.

 

Keywords: asthma, children, lymphocytes, basophils.

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