S.S. Masalskiy1,2, A.S. Kalmykova1, O.P. Ukhanova1
1 Stavropol state medical university, Stavropol, Russia
2 SCCC Allergology and Immunology, Moscow, Russia
The article presents materials comparing the blood concentrations vitamin D in patients with mild and moderate bronchial asthma (27.16±9.75 ng / ml and 19.65±7.25 ng / ml, respectively, p <0.05). Serum concentration of vitamin D impact on severity allergic asthma and the number of exacerbations per year. Low concentrations of vitamin D increase the risk of severe asthma (OR =0.895, 95% CI 0.830–0.965) and frequent exacerbations (OR=0.927, 95% CI 0.869–0.928). When studying the effect of insolation on the concentration of vitamin D in children and adolescents, Degree of calciferol was deferent between seasons (p<0.05). The patients examined in the summer had higher levels of serum 25(OH)D, then who observed in the winter. Deficiency and insufficiency of vitamin D in children with moderate asthma, were observed more often mild asthma regardless of the season. In summer, patients with moderate asthma did not reach normal 25(OH)D concentrations in the blood without vitamin D3 therapy.
Keywords: asthma, vitamin D3, children, teenager, exacerbation, severity.