REVIEW. ANTIHISTAMINES IN THERAPY OF ALLERGIC RHINITIS

P. 5-13

S.S. Masalskiy, Y.S. Smolkin

 

Scientific and clinical advisory center of an allergology and immunology, Moscow, Russia

NRC Institute of Immunology FMBA of Russia, Moscow, Russia

 

The article describes a phenotypic approach to the treatment of allergic rhinitis (AR), according to modern guidelines from the standpoint of evidence-based medicine. An algorithm for the treatment of AR is formulated for the practical doctor. In most cases, the first line of treatment is antihistamines. As a second-line therapy, a combination of antihistamine and topical glucocorticosteroids is used in various forms. Leukotriene receptor antagonists can be considered as an alternative therapy in special cases. A review of existing meta-analyzes of the effectiveness of therapy in AR allows us to consider cetirizine as one of the most effective drugs with a high safety

profile.

 

Keywords: allergic rhinitis, cetirizine, antihistamines, children, review.

 

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