Toxic epidermal necrolysis in 12 year old girl. Efficacy of combined therapy intravenous

immunoglobulins (IVIG) and steroids р. 18-21

R.Y. Meshkova, Y.A. Vavilenkova, L.V. Sasonenkova, E.V. Volkova, E.A. Grischenko, T.A. Dihtjarenko


Smolensk State Medical Univercity, Smolensk, Russia

Regional Center of Allergology and Immunology, Smolensk, Russia


Toxic epidermal necrolysis is the most severe form of bullous skin diseases. They are classified

(excluding MEE) into three clinical variants according to the affected body surface area: 1) less thаn 10% of body surface area – SJS, 2) 10% to 30% of body surface area – SJS or partial TEN, 3) more than 30% – TEN. Medications are one of the most common causes of TEN. Mortality due to TEN can reach up to 12,5%. Combined use of IVIG and steroids might be an effective treatment of TEN. Here we discuss a case of TEN in 12 year old girl following 14 days of sulfasalazine administration for ulcerative colitis. The disease progressed through three stages: from MEE to SJS and subsequently to TEN. Combined therapy with IVIG and systemic steroids resulted in positive therapeutic effect.


Keywords: bullous dermatitis, toxic epidermal necrolysis, intravenous immunoglobulins, corticosteroids.