Skin dendritic cells p. 20-32

E.A. Grishchenko


Scientific and clinical advisory center of an allergology and immunology, Moscow, Russia


The two main populations of dendritic cells (DCs) present in normal human skin are epidermal Langerhans’ cells (LCs) and dermal DCs. DCs are without a doubt important key skin cells that connect information from the environment with the innate and adaptive immune system. Their function is decisive for the initiation and inhibition of immune responses, and therefore they play a central role for both the healthy and diseased states of the skin. The significant contribution of skin DCs to pathogenesis of the atopic dermatitis (AD), allergic, irritant contact dermatitis, psoriasis makes these cells important therapeutic targets.


Keywords: dendritic cells (DCs), Langerhans’ cells (LCs), dermal DCs, atopic dermatitis, contact dermatitis, psoriasis.