Interleukin-1 in gastric mucus in children with functional dyspepsia as a predictor of chronic inflammation of gastrointestinal tract mucosa p. 25-29

D.V. Pechkurov 1, N.B. Migacheva 1, U.E. Allenova 2


1 Samara State Medical University, Samara, Russia

2 Penza Regional Children’s Clinical Hospital named after N.F. Filatov, Penza, Russia


Inflammatory potential of the gastrointestinal mucosa is of considerable interest from the point of view of chronic inflammation development in children with functional digestive disorders. Interleukin-1 is a key proinflammatory cytokine. Its level in tissue increases in acute inflammation, and the retention of its active production may be one of the causes and predictors of a chronic inflammation process. In the current study we determined the level of IL-1 in the gastric mucus in children with different variants of functional dyspepsia (H. pylori-negative and H. pylori positive), as well as in children with identified by esophagogastroduodenoscopy erosions or ulcers of the upper gastrointestinal tract. The data indicate significant differences in the levels of IL-1 in children with different variants of gastrointestinal pathology and dispute the idea that functional dyspepsia can be considered as the initial stage of organic pathology of gastrointestinal tract.


Keywords: functional dyspepsia, interleukin-1.