Intestinal dendritic cells p. 31-40

E.A. Grishchenko


Scientific and clinical advisory center of an allergology and immunology, Moscow, Russia


Dendritic cells (DCs) within the intestinal compartments have been extensively studied and much

is now known regarding their phenotype. DCs are essential modulators of the immune system as they maintain the balance between immunogenic and tolerogenic immune responses in the intestine. Gutassociated DCs play a key role in the in duction of Treg cells and maintaining immunological tolerance. Dysregulation of DCs function can result in severe intestinal inflammation. Given the pivotal role of DCs in regulating the balance between immunity and tolerance, much effort has been put into the generation of tolerogenic DCs in recent years. The efficacy of treatments for food allergy, such as oral allergen immunotherapy (OIT) or sublingual

allergen immunotherapy (SLIT), might be enhanced by the use of adjuvants designed to enhance the tolerogenic properties of DCs.


Key words: intestinal dendritic cells, oral tolerance, food allergy.