N.N. Kaladze, M.L. Babak, A.I. Ezernitskaya, A.I. Gordienko
V.I. Vernadsky Crimean Federal University
Medical Academy named after S.I. Georgievsky of Vernadsky CFU
A significant (p<0.05) decrease in the level of epidermal growth factor in the blood serum (75.63±18.74 рg/ml) by 59.6% compared to the control group (187.07±49.28 рg/ml) Was detected in 36 patients during the period of bronchial asthma remission, which arrived at the sanatorium-resort stage of rehabilitation. This indicated the preservation of an inflammatory reaction in the body of sick children, even during the remission of the disease. The average size of the epidermal growth factor depended on the degree of the disease. Its magnitude was reduced at all stages of treatment of asthma. The level of epidermal growth factor was 54.0% lower than the control values for stage I disease, at stage II of treatment — 51.22%, at III stage of treatment — 4.94 times. The average epidermal growth factor increased to 184.24±20.03 рg/ml after the combined therapy, which practically reached the level of the control value.
Keywords: bronchial asthma, children, epidermal growth factor.